ABSTRACT
Thromboembolic diseases are major health problems worldwide,and remain the leading cause of mortality and disabil-ity at present.Bleeding is the most important complication of an-tithrombotic therapy for thromboembolism,therefore research and development of new antithrombotic drugs with lowered bleeding risk is a significant medical need.The data that elevated plasma levels of FXI are associated with thromboembolic diseases,se-vere FXI deficiency reduced incidence of DVT and ischemic stroke,and FXI deficiency or inhibition in animals shows protec-tive effects against thrombus formation supporting FXI as a novel antithrombotic target with lowered bleeding risk.This paper re-views the progress on FXI as a novel antithrombotic target and the inhibitors target FXI.
ABSTRACT
Promoting bilingual teaching is an important part of reforms in higher education and also a need for training high-quality medical talents.This article discusses practice of bilingual teaching of human parasitology and analyzes the problems in teaching.
ABSTRACT
Nematoda anticoagulant protein c2((NAPc2)) is a protein originally isolated from the canine hookworm Ancylostoma caninum.NAPc2 binds to a noncatalytic site on fⅩa then selectively inhibits fVⅡa/TF complex.NAPc2 is proven to be a safe and potent anticoagulant in Phase Ⅰ and Phase Ⅱ clinical trials,and it has prolonged elimination half-life(longer than 50 h).In a word,NAPc2 may play a promising role in the prevention and treatment of thrombosis,disseminated intravascular coagulopathies(DIC) and tumor.